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research

research

Scientific research is the basis of our work: we constantly study and experiment, and we start to work the new product only when the results confirm all its benefits. Many publications have opened up new directions for nutraceuticals over the years.

  • Mollace V. et al. The protective effect of bergamot oil extract on lecitine- like oxy LDL receptor-1 expression in balloon injury – related neo intima formation. J Cardiovasc Pharmacol Ther. 2008 Jun; 13(2): 120-9
  • Mollace et al., Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 2011 Apr; 82(3): 309-16
  • Gliozzi et al., Bergamot polyphenolic fraction enhances rosuvastatin- induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. Int J Cardiol. 2013 Dec 10; 170(2): 140-5
  • Nisticò et al., Telomere and telomeras emodulation by bergamot polyphenolic fraction in experimental photoageing in human Keratinocytes. J Biol Regul Homeost Agents. 2015 Jul-Sep; 29(3): 723-8
  • Parafati et al., Bergamot polyphenol fraction prevents non alcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet inducedrat model of metabolic syndrome. J Nutr Biochem. 2015 Sep; 26(9): 938-48
  • Gliozzi et al., The effect of bergamot polyphenolic fraction in patients with non alcoholic liver steatohepatitis and metabolic syndrome. PharmaNutrition. 2015 Nov
  • Mollace et al., Bergamot poliphenolic fraction counteracts erectile dysfunction occurring in patients suffering from type 2 diabetes. Pharmanutrition. 2015 Nov
  • Lauro et al., Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice. PLoS One. 2016 May 26; 11(5)
  • Musolino et al., Lipid lowering effect of bergamot polyphenolic fraction: role of pancreatic cholesterol ester hydrolase. J Biol. Regul. Homeost. Agents. 2017 Oct-Dec; 31(4): 1087-1093
  • Carresi et al., Anti-oxidant effect of Bergamot polyphenolic fraction counter acts Doxorubicin-induced cardiomyopathy: role of autophagy and c-kitposCD45negCD31neg cardiac stem cell activation. Carresi C., Mollace V J. Mol. Cell. Cardio. 2018
  • Buloca et al., Cynaropicrin, a sesquiterpene lactone/major component of the leaves of Cynaracardunculus, blocks the growth of anaplastic thyroid carcinoma cells by inhibiting STAT3 phos- phorylation. J. Met. End. Immune Dis: Drug targets. 2018
  • Tang X et al., Protective Effects of Ethanolic Extracts from Arti- choke, an Edible Herbal Medicine, against Acute Alcohol – Induced LiverInjury in Mice. Nutrients. 2017
  • Ben Salem et al., Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxandiabetic rats. BMC Complement. AlternMed. 2017
  • Pulito et al., Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion, Oncotarget. 2015
  • Rondanelli et al., Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynaras colymus: a double-blind, placebo-controlled, randomized clinical trial. Phytother Res. 2014
  • Rondanelli et al., Pilot study on the efficacy of once a day dosage (200 mg) of Cynara scolymus L. leaf extract on HDL-cholesterol and on lipidic pacern in a group of adult subjects with mild hypercholesterolemia. Phytother Res. 2012
  • Zaru et al., Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on operant self-administration of a chocolate-flavoured beverage in rats. Phytother Res. 2013

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